The objective of the present study was the formulation and characterization of floating drug delivery system of tolperisone hydrochloride, which would remain in stomach and/or upper part of GIT for prolonged period of time. The floating tablets of tolperisone hydrochloride were prepared by direct compression method using various polymers like HPMC K100M and PEO N12K were used in various concentrations. The formulations were evaluated for hardness, friability, weight variation, swelling index, floating lag time, floating time, % CDR etc. From the results obtained, batch F10 showed the lowest lag time of 32.27±1.89 sec and the highest % CDR of 86.46±1.22. Tolperisone Hydrochloride was formulated as floating tablets to give sustained effect using various polymers and crosspovidone used as matrix ballooning inducer. From the results obtained, it was found that concentration of polymer and crosspovidone played important role in achieving desired lag time, floating time and % CDR of the formulated tablets. Hence the optimum concentration of HPMC K100M and crosspovidone were required to formulate floating tablets to increase GRT. From the results obtained, it was concluded that the optimized formulation containing HPMC K100M and crosspovidone shows better swelling properties with desired drug release properties and floating behaviour. Hence HPMC K100M is a potential polymer candidate for formulation of sustained release floating non effervescent tablets.
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